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A SEQUENCE OF ACYLAMINATION AND ACYLATION REACTIONS IN POLYPHOSPHORIC ACID – A NOVEL APPROACH TO THE FRIEDLÄNDER SYNTHESIS OF 2-ARYLQUINOLINES

Игорь Ю. Гришин, Владимир В. Малюга, Дмитрий А. Аксенов, Никита К. Кирилов, Гасан М. Абакаров, Сергей Н. Овчаров, Андрей В. Сарапий, Николай А. Аксенов, Александр В. Аксенов
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Abstract


A method for the synthesis of 2-(2-acylaminoaryl)quinolines was developed based on a one-pot sequence of direct electrophilic acylamination of arenes with nitroalkanes in polyphosphoric acid and acylation at the ortho-position with respect to the acylamino group.

 


Keywords


nitro compounds; polyphosphoric acid; quinolines; acylamination; one-pot synthesis.

Full Text: PDF (Russian) Supplementary File(s): Supplementary information (1001KB)


 

 

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