A SEQUENCE OF ACYLAMINATION AND ACYLATION REACTIONS IN POLYPHOSPHORIC ACID – A NOVEL APPROACH TO THE FRIEDLÄNDER SYNTHESIS OF 2-ARYLQUINOLINES

Authors

  • Игорь Ю. Гришин North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Владимир В. Малюга North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Дмитрий А. Аксенов North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Никита К. Кирилов North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Гасан М. Абакаров Dagestan State Technical University, 70 Shamilya St., Makhachkala 367010, Dagestan, Russ
  • Сергей Н. Овчаров North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Андрей В. Сарапий North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Николай А. Аксенов North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia
  • Александр В. Аксенов North Caucasus Federal University, 1a Pushkina St,, Stavropol 355017, Russia

DOI:

https://doi.org/10.1007/6796

Keywords:

nitro compounds, polyphosphoric acid, quinolines, acylamination, one-pot synthesis.

Abstract

A method for the synthesis of 2-(2-acylaminoaryl)quinolines was developed based on a one-pot sequence of direct electrophilic acylamination of arenes with nitroalkanes in polyphosphoric acid and acylation at the ortho-position with respect to the acylamino group.

 

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Published

2022-07-21

Issue

Vol. 58 No. 6/7 (2022)

Section

Original Papers