A SILICA-SUPPORTED ORTHOPHOSPHORIC ACID (H<sub>3</sub>PO<sub>4</sub>·SiO<sub>2</sub>) AS AN ENVIRONMENTALLY FRIENDLY, HETEROGENEOUS CATALYST FOR ONE-POT SYNTHESIS OF 4-SUBSTITUTED 1,5-BENZODIAZEPINES

Authors

  • Minal Kattimani Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
  • Poonam Khyadage Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
  • Satish Mitragotri Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
  • Makarand Kulkarni Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
  • Prakash Wadagaonkar Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Pune-411 008

Keywords:

aldehydes, dimedone, o-phenylenediamine, silica-supported orthophosphoric acid, 4-substituted 1,5-benzodiazepine

Abstract

An efficient, environmentally friendly protocol was developed for the synthesis of 4-substituted 1,5-benzodiazepines via a one-pot threecomponent reaction. o-Phenylenediamines, dimedone, and aldehydes were reacted in the presence of silica-supported orthophosphoric acid (H3PO4·SiO2) as an environmentally friendly, heterogeneous catalyst at 70°C to produce 4-substituted 1,5-benzodiazepines. High to excellent yields, metal-free, environmentally friendly, reusable catalyst, and faster reactivity are the notable features of the developed protocol.

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Published

2026-02-24

Issue

Vol. 61 No. 9/10 (2025): Modern catalytic approaches for the assembly and functionalization of heterocyclic compounds

Section

Original Papers