A SILICA-SUPPORTED ORTHOPHOSPHORIC ACID (H3PO4·SiO2) AS AN ENVIRONMENTALLY FRIENDLY, HETEROGENEOUS CATALYST FOR ONE-POT SYNTHESIS OF 4-SUBSTITUTED 1,5-BENZODIAZEPINES

Minal Kattimani; Poonam Khyadage; Satish Mitragotri; Makarand Kulkarni; Prakash Wadagaonkar

A SILICA-SUPPORTED ORTHOPHOSPHORIC ACID (H3PO4·SiO2) AS AN ENVIRONMENTALLY FRIENDLY, HETEROGENEOUS CATALYST FOR ONE-POT SYNTHESIS OF 4-SUBSTITUTED 1,5-BENZODIAZEPINES

Авторы

Minal Kattimani Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
Poonam Khyadage Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
Satish Mitragotri Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
Makarand Kulkarni Department of Chemistry, Walchand College of Arts and Science, Solapur 413 006
Prakash Wadagaonkar Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Pune-411 008

Ключевые слова:

aldehydes, dimedone, o-phenylenediamine, silica-supported orthophosphoric acid, 4-substituted 1,5-benzodiazepine

Аннотация

An efficient, environmentally friendly protocol was developed for the synthesis of 4-substituted 1,5-benzodiazepines via a one-pot threecomponent reaction. o-Phenylenediamines, dimedone, and aldehydes were reacted in the presence of silica-supported orthophosphoric acid (H₃PO₄·SiO₂) as an environmentally friendly, heterogeneous catalyst at 70°C to produce 4-substituted 1,5-benzodiazepines. High to excellent yields, metal-free, environmentally friendly, reusable catalyst, and faster reactivity are the notable features of the developed protocol.