SYNTHESIS AND CYTOTOXICITY OF METHYL- AND METHOXY-SUBSTITUTED METAL 8-QUINOLINETHIOLATES

Authors

  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Зарума Inorganic Chemistry Institute, Riga Technical University, Salaspils LV-2169
  • Я. Ашакс Inorganic Chemistry Institute, Riga Technical University, Salaspils LV-2169
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Гулбе Latvian Institute of Organic Synthesis, Riga LV-1006
  • В. Бридане Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/7055

Keywords:

metal 3- and 5-methyl-8-quinolinethiolates, metal 2- and 6-methoxy-8-quinolinethiolates, synthesis, toxicity, cytotoxicity

Abstract

It has been found that the nature of the substituent, its position in the quinoline ring, and the nature of the metal significantly affect the antitumor activity and toxicity of metal 8-quinolinethiolates. The most cytotoxic towards human fibrosarcoma HT-1080 and  mouse hepatoma MG-22A tumor cells are the 6-methoxy-8-quinolinethiolates of rhodium, osmium, iridium, indium, antimony, and bismuth, however these are highly toxic towards normal mouse embryonic NIH 3T3 fibroblasts. The iridium 5-methyl-8-quinolinethiolate is somewhat less active to MG-22A cells but shows quite good selectivity of action because of its markedly lower toxicity. 

How to Cite
Lukevics, E.; Zaruma, D.; Ashaks, J.; Shestakova, I.; Domracheva, I.; Gulbe, A.; Bridane, V.  Chem. Heterocycl. Compd. 2008, 44, 559. [Khim. Geterotsikl. Soedin. 2008, 711.]

For this article in the English edition see DOI 10.1007/s10593-008-0075-8


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Published

2022-09-15

Issue

No. 5 (2008)

Section

Original Papers