Synthesis of 6,8-substituted derivatives of imidazo[5,1-<i>c</i>][1,2,4]triazines and 1,4-dihydroimidazo[5,1-<i>c</i>][1,2,4]triazin-4-ones

Abstract

The cyclization of imidazolylhydrazines, synthesized from 5-diazoimidazoles and cyanoacetic acid derivatives, to 4-aminoimidazo[5,1-c][1,2,4]triazines and imidazo[5,1-c][1,2,4]triazin-4-ones has been studied. It was established that electron-withdrawing substituents at position 4 of the imidazole ring had a weak effect on the cyclization process. On the other hand, electron-donating substituents at positions 4 or 2 of this ring inhibited and in some cases completely prevented the formation of bicyclic products.

How to Cite
Bezmaternykh, M. A.; Mokrushin, V. S.; Pospelova, T. A.; El'tsov, O. S. Chem. Heterocycl. Compd. 1998, 34, 702. [Khim. Geterotsikl. Soedin. 1998, 34, 805.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02252280