Derivatives of octahydropyrrolo[4,3,2-<i>m</i>,<i>n</i>]-acridine. 5. Alkylation of 1-methyl and 1-aryl-4,4,8,8-tetramethyl-2,3,4,5,7,8,9,10-octahydropyrrolo[4,3,2-<i>m</i>,<i>n</i>]acridin-10-ones

Authors

  • Я. Р. Улдрикис Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. А. Бисениекс Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Я. Дубурс Latvian Institute of Organic Synthesis, Riga LV-1006

Abstract

4,4,8,8-Tetramethyl-2,3,4,5,7,8,9,10-octahydropyrrolo[4,3,2-m,n]acridin-10-ones were alkylated at the nitrogen atom of the pyrrole ring by successive treatment with sodium hydride and an alkyl halide. Treatment of the neutral molecule with methyl iodide gave alkylation at the nitrogen atom of the pyridine ring. Derivatives of pyrrolo[4,3,2-m,n]acridine with no substituent at position 2 readily lost a proton from the NH group of the pyrrole ring to give bipolar structures.

How to Cite
Uldrikis, Y.; Bisenieks, É.; Duburs, G. Chem. Heterocycl. Compd. 1998, 34, 692. [Khim. Geterotsikl. Soedin. 1998, 34, 794.]

For this article in the English edition, see DOI  https://doi.org/10.1007/BF02252278

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Published

1998-06-25

Issue

No. 6 (1998)

Section

Original Papers