Synthesis of 2-substituted cinchoninic acid amides and their cyclization into 1,2,4-triazolo[4,3-<i>a</i>]quinoline-9- and 1,2,4-triazino[4,3-<i>a</i>]quinoline-10-carboxylic acid amides

Abstract

Substituted amides of 2-hydrazino- and 2-ethylhydrazinocinchoninic acids react with pyruvic acid and its ethyl ester to give amides of 3-methyl-4-oxo-1,2,4-triazino[4,3-a]quinoline-10-carboxylic acid. On reaction with aromatic aldehydes they are converted into amides of 2-ethyl-3-phenyl-2,3-dihydro-1,2,4-triazolo[4,3-a]quinoline-9-carboxylic acid, or, in the case of unsubstituted hydrazines, into amides of 2-arylidene-hydrazinocinchoninic acid, which was oxidized to substituted 1,2,4-triazolo[4,3-a]quinolines.

How to Cite
Mikhalev, A. I.; Kon'shin, M. E.; Vakhrin, M. I. Chem. Heterocycl. Compd. 1997, 33, 609. [Khim. Geterotsikl. Soedin. 1997, 701.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02291948