Synthesis of 1,4-dihydropyridine derivatives having an oxy-, alkoxy-, or dimethylaminophenyl substituent in the 4 position, their antioxidant activity, and their binding to phospholipid membranes

Authors

  • M. Плотниеце Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Тиpзитис Latvian Institute of Organic Synthesis, Riga LV-1006
  • Я. Улдрикис Latvian Institute of Organic Synthesis, Riga LV-1006
  • Ж. Коронова Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Тирзите Latvian Institute of Organic Synthesis, Riga LV-1006
  • H. Макарова Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Дубурс Latvian Institute of Organic Synthesis, Riga LV-1006

Abstract

The method of Hantzsch was used to synthesize esters and amides of 2,6-dimethyl-4-aryl-1,4-dihydropyridine-3,5-dicarboxylic acid, containing electron donor substituents in the phenyl ring. It was found that in addition to their antioxidant properties, 3,5-diamides and 4-(3′,4′-dioxyphenyl) derivatives have an affinity for model phospholipid membranes.

How to Cite
Plotnietse, M.; Tirzitis, G.; Uldrikis, Y.; Koronova, Zh.; Tirzite, D.; Makarova, N.; Duburs, G. Chem. Heterocycl. Compd. 1996, 32, 1166. [Khim. Geterotsikl. Soedin. 1996, 1358.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169228

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Published

1996-10-25

Issue

No. 10 (1996)

Section

Original Papers