Synthesis and steric structure of 4-arylaminohexahydropyrimidine-2-thiones

Abstract

Reaction of 4-hydroxy- and 4methoxyhexahydropyrirnidine-2-thiones and 6-methyl-1,2,3,6-tetrahydropyrimidine-2-thione with primary amines occurs readily in the presence of acidic or basic catalysts to give 4-arylaminohexahydropyrimidine-2-thiones both regio- and stereoselectively. It was shown that reaction stereoselectivity depends on the structure of the starting materials and on the reaction conditions. The steric structures of the products synthesized has been studied.

How to Cite
Shutalev, A. D.; Pagaev, M. T.; Ignatova, L. A. Chem. Heterocycl. Compd. 1994, 30, 943. [Khim. Geterotsikl. Soedin. 1994, 1093.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01165034