Synthesis of nitrogen containing heterocycles over copper chromite

Abstract

The reactions of 1,2-diaminopropane, 1-amino-2-propanol, 1-amino-2-ethanol and N-(β-aminoethyl)-1,2-diaminoethane in the gas phase over copper chromite have been investigated with the objective of synthesising nitrogen containing heterocycles. At 240–360°C 1,2-diaminopropane gave principally methyl- and 2,5-dimethylpyrazine, whereas the basic reaction for 1-amino-2-propanol was dehydration to give 1-aminoethyl-2-methylaziridine (with a selectivity of up to 78%). The main cyclic product from the dehydration of 1-amino-2-ethanol was pyrazine, while piperazine was farmed together with pyrazine from N-(β-amonoethyl)-1-2-diaminoethane.

How to Cite
Meksh, P. A.; Anderson, A. A.; Shimanska, M. Chem. Heterocycl. Compd. 1994, 30, 822. [Khim. Geterotsikl. Soedin. 1994, 950.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169640