New reaction of benzocrown derivatives of 5-amino-4-imidazolecarboxamides leading to condensed tetracyclic systems

Abstract

A new cyclization reaction has been described for 5-amino-4-imidazolecarboxamides containing a benzocrown ether fragment at N₍₁₎ by the action of nitrous acid, which proceeds at the amino group of the imidazole ring and benzene ring of the macroheterocyclic fragment instead of the expected closure of the triazine ring to give a 2-azapurine analog, namely, 1-R-imidazo[4,5-d]triazin-4-one, where R is the benzo-12-crown-4 or benzo-15-crown-5 residue.

How to Cite
edorov, G. V.; Shapiro, Yu. E.; Ivanov, É. I.; Mazepa, A.V.; Krasnoshchekaya, S. P. Chem. Heterocycl. Compd. 1993, 29, 1156. [Khim. Geterotsikl. Soedin. 1993, 1349.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF00538060