NEW METHOD FOR THE SYNTHESIS OF DIFFICULTLY AVAILABLE STERICALLY HINDERED TRITIUM-LABELED PYRIDINIUM DERIVATIVES

Authors

  • Н. Е. Щепина Natural Sciences Institute, Perm State University, Perm 614990
  • В. В. Аврорин St. Petersburg State University, St. Petersburg 199034
  • Г. А. Бадун M. V. Lomonosov Moscow State University, Moscow 119991
  • В. М. Федосеев M. V. Lomonosov Moscow State University, Moscow 119991
  • С. Б. Льюис James Madison University, Harrisonburg, VA

DOI:

https://doi.org/10.1007/2968

Keywords:

nucleogenic phenyl cations, N-phenyl-2, 6-lutidinium and N-phenyl-2, 4, 6-collidinium salts, tritium, direct phenylation of pyridine nitrogen atom

Abstract

Direct phenylation of the nitrogen atom in pyridines was noted in a study of the ion-molecule reactions of free nucleogenic phenyl cations generated by β-decay of tritium in labeled benzene. A one-step synthesis of unreported biologically active tritium-labeled N-phenyl-2,6-lutidinium and 2,4,6-collidinium salts. Steric factors, which significantly reduce the yield in the case of sym-collidine, play a major role in the direct phenylation of nitrogen.

How to Cite
Shchepina, N. E.; Avrorin, V. V.; Badun, G. A.; Fedoseev, V. M.; Lewis, S. B. Chem. Heterocycl. Compd. 2010, 46, 547. [Khim. Geterotsikl. Soedin. 2010, 692.]

For this article in the English edition see DOI 10.1007/s10593-010-0544-8

Downloads

Published

2016-01-15

Issue

No. 5 (2010)

Section

Original Papers