THE PICTET-SPENGLER REACTION IN THE SYNTHESIS OF CONDENSED BENZODIAZEPINES. 1. SYNTHESIS OF 6,11,12,14-TETRAHYDROBENZO[4,5][1,2]DIAZEPINO[7,1-<i>b</i>]QUINAZOLIN-14-ONES

Authors

  • А. С. Толкунов L. M. Litvinenko Institute of Physical-Organic and Coal Chemistry, Ukraine National Academy of Sciences
  • А. И. Хижан L. M. Litvinenko Institute of Physical-Organic and Coal Chemistry, Ukraine National Academy of Sciences
  • С. Л. Богза L. M. Litvinenko Institute of Physical-Organic and Coal Chemistry, Ukraine National Academy of Sciences

DOI:

https://doi.org/10.1007/2979

Keywords:

3-amino-2-(1, 4-benzodioxan-6-ylmethyl)quinazolin-4(3H)-one, 3-amino-2-(3, 4-dimethoxybenzyl)quinazolin-4(3H)-one, condensed diazepines, hydrochloric acid, tetrahydrobenzo[4, 5][1, 2]diazepino[7, 1-b]quinazolin-14-ones, trifluoroacetic acid, the Pictet-Spengler reaction, cyclization

Abstract

A new strategy is proposed for the synthesis of the seven-membered heterocyclic skeleton of tetrahydro[4,5][1,2]diazepino[7,1-b]quinazolin-14-ones based on the Pictet-Spengler reaction of 3‑amino-2-(3,4-dimethoxybenzyl)quinazolin-4(3H)-one with aromatic aldehydes and paraform in acid media.

How to Cite
Tolkunov, A. S.; Khizhan, A. I.; Bogza, S. L. Chem. Heterocycl. Compd. 2010, 46, 592. [Khim. Geterotsikl. Soedin. 2010, 745.]

For this article in the English edition see DOI 10.1007/s10593-010-0550-x

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Published

2016-01-18

Issue

No. 5 (2010)

Section

Original Papers