4-HYDROXY-2-QUINOLONES. 191. SYNTHESIS, TAUTOMERISM AND BIOLOGICAL ACTIVITY OF BENZIMIDAZOL-2-YLAMIDES OF 1-R-4-HYDROXY- 2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS

Authors

  • Б. В. Украинец National Pharmaceutical University, Kharkiv 61002
  • Л. А. Гриневич National Pharmaceutical University, Kharkiv 61002
  • А. А. Ткач National Pharmaceutical University, Kharkiv 61002
  • О. В. Горохова National Pharmaceutical University, Kharkiv 61002
  • В. Н. Кравченко National Pharmaceutical University, Kharkiv 61002
  • Г. Сим Far East State Medical University, Khabarovsk 68000

DOI:

https://doi.org/10.1007/6151

Keywords:

2-aminobenzimidazole, 4-hydroxy-2-oxo-1, 2 dihydroquinoline-3 carboxamides, antithyroid activity, antituberculosis activity, tautomerism

Abstract

A series of benzimidazol‑2‑ylamides of 4‑hydroxy‑2‑oxo‑1,2‑dihydroquinoline‑3‑carboxylic acids was prepared in a search for biologically active compounds. These compounds exist in the crystal exclusively in the amide form, while in solution amide↔imide tautomerism is observed. The results of a study of the antithyroid and antituberculosis activities of these compounds are given.

How to Cite
Ukrainets, I. V.; Grinevich, L. A.; Tkach, A. A.; Gorokhova, O. V.; Kravchenko, V. N.; Sim, G.  Chem. Heterocycl. Compd. 2011, 46, 1364. [Khim. Geterotsikl. Soedin. 2010, 1681.]

For this article in the English edition see DOI 10.1007/s10593-011-0673-8

 

 

 

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Published

2021-02-12

Issue

No. 11 (2010)

Section

Original Papers