4-HYDROXY-2-QUINOLONES. 144. ALKYL-, ARYLALKYL-, AND ARYLAMIDES OF 2-HYDROXY-4-OXO-4H-PYRIDO[1,2-<i>a</i>]PYRIMIDINE-3-CARBOXYLIC ACID AND THEIR DIURETIC PROPERTIES

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkiv 61002
  • И. А. Тугайбей Kharkiv Medicinal Academy of Postgraduate Education, Kharkiv 61176
  • Н. Л. Березнякова National Pharmaceutical University, Kharkiv 61002
  • В. Н. Кравченко National Pharmaceutical University, Kharkiv 61002
  • А. В. Туров Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/7056

Keywords:

amides, 2-hydroxy-4-oxo-4H-pyrido-[1, 2-a]pyrimidine-3-carboxylic acids, tricarbonylmethane heterocyclic derivatives, diuretic activity, X-ray structural analysis

Abstract

Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view to establishing a structure–biological activity relationship. A comparative analysis has been made of their diuretic properties and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.

How to Cite
Ukrainets,I. V.; Tugaibei, I. A.; Bereznyakova, N. L.; Kravchenko, V. N.; Turov, A. V.  Chem. Heterocycl. Compd. 2008, 44, 565. [Khim. Geterotsikl. Soedin. 2008, 718.]

For this article in the English edition see DOI 10.1007/s10593-008-0076-7


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Published

2022-09-15

Issue

No. 5 (2008)

Section

Original Papers