PREPARATION OF 1-AMINO-4-METHYLPIPERAZINE

Authors

  • П. М. Кушакова Saint-Petersburg State Technical University, Saint-Petersburg 190013
  • А. Н. Чернобровый "Olainfarm", Riga LV-2114
  • В. А. Кузнецов Saint-Petersburg State Technical University, Saint-Petersburg 190013
  • А. В. Гарабаджиу Saint-Petersburg State Technical University, Saint-Petersburg 190013

DOI:

https://doi.org/10.1007/8421

Keywords:

1-amino-4-methylpiperazine, haloalkylamines, N, N-di(2-chloroethyl)methylamine, N-(2-chloroethyl)-N-methylaziridinium chloride, N-(2-chloroethyl)-N-(2-hydrazinoethyl)methylamine

Abstract

The selectivity of the formation of N-di(2-chloroethyl)methylamine in reactions with various chlorinating agents has been investigated and the  optimum  chlorinating agent has been found. 1-Amino-4-methylpiperazine  has been obtained for the first time by the cyclization of N-di(2-chloroethyl)methylamine with aqueous hydrazine.  A possible mechanism has been proposed  for  the cyclization reaction.

How to Cite
Kushakova, P. M.; Chernobroviy, A. N.; Kuznetsov, V. A.; Garabadgiu, A. V.  Chem. Heterocycl. Compd. 2004, 40, 1546. [Khim. Geterotsikl. Soedin. 2004, 1794.]

For this article in the English edition, see DOI 10.1007/s10593-005-0097-4


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Published

2023-12-08

Issue

No. 12 (2004)

Section

Original Papers